The Carolina Panthers and Kansas City Chiefs played each other in the regular season and playoffs 7 times in league history. Kansas City Chiefs 5 games and Carolina Panthers won 2 games in their all-time meeting here listed below.
Kansas City Chiefs lead all time series 5-2-0.
| Opponent | Date | Results |
| Carolina Panthers @ Kansas City Chiefs | 11/08/2020 | 31-33 (Chiefs) |
| Kansas City Chiefs @ Carolina Panthers | 11/13/2016 | 20-17 (Chiefs) |
| Carolina Panthers @ Kansas City Chiefs | 12/02/2012 | 21-27 (Chiefs) |
| Kansas City Chiefs @ Carolina Panthers | 10/05/2008 | 0-34 (Panthers) |
| Carolina Panthers @ Kansas City Chiefs | 09/19/2004 | 28-17 (Panthers) |
| Carolina Panthers @ Kansas City Chiefs | 12/10/2000 | 14-15 (Chiefs) |
| Kansas City Chiefs @ Carolina Panthers | 09/21/1997 | 35-14 (Chiefs) |
