The 2021-22 NFL Week 7 game will kick off on Thursday, October 21 with a game where the Cleveland Browns host the Denver Broncos at 8:20 pm ET on NFLN, and Week 7 games will be ended with a game where the New Orleans Saints will visit Seattle Seahawks Monday, October 25 at 8:15 pm ET on ESPN.
Thursday, October 20
| Matchup | Time (ET) | TV | Arena Location |
| Saints @ Cardinals | 8:15 PM | Prime Video | State Farm Stadium, Glendale |
Sunday, October 23
| Matchup | Time (ET) | TV | Arena Location |
| Falcons @ Bengals | 1:00 PM | FOX | Paul Brown Stadium, Cincinnati |
| Lions @ Cowboys | 1:00 PM | CBS | AT&T Stadium, Arlington |
| Colts @ Titans | 1:00 PM | CBS | Nissan Stadium, Nashville |
| Packers @ Commanders | 1:00 PM | FOX | FedExField, Landover |
| Buccaneers @ Panthers | 1:00 PM | FOX | Bank of America Stadium, Charlotte |
| New York @ Jaguars | 1:00 PM | FOX | TIAA Bank Field, Jacksonville |
| Browns @ Ravens | 1:00 PM | CBS | M&T Bank Stadium, Baltimore |
| New York @ Broncos | 4:05 PM | CBS | Empower Field at Mile High, Denver |
| Texans @ Las Vegas | 4:05 PM | CBS | Allegiant Stadium, Las Vegas |
| Seahawks @ Los Angeles | 4:25 PM | FOX | SoFi Stadium, Inglewood |
| Chiefs @ 49ers | 4:25 PM | FOX | Levi’s Stadium, Santa Clara |
| Steelers @ Dolphins | 8:20 PM | NBC | Hard Rock Stadium, Miami Gardens |
Monday, October 24
| Matchup | Time (ET) | TV | Arena Location |
| Bears @ Patriots | 8:15 PM | ESPN | Gillette Stadium, Foxboro |