The 2021-22 NFL Week 16 game will kick off on Thursday, December 23 with a game where the Tennessee Titans will host the San Francisco 49ers at 8:20 p.m. ET for Thursday football live on FOX, and Week 16 football will be ended with a Monday football game where the Miami Dolphins will visit New Orleans Saints on Monday, December 27 at 8:15 pm ET live on ESPN.
When is Thursday night football of NFL Week 16 in 2021?
The upcoming Thursday night football will take place on Thursday, December 23, 2021, at Nissan Stadium, Tennessee between the San Francisco 49ers vs Tennessee Titans tip off set for 8:20 p.m. ET live on the NFLN network.
When is Sunday night football of NFL Week 16 in 2021?
The Washington Football Team will visit the Dallas Cowboys for Sunday night football on Sunday, December 26, 2021, at AT&T Stadium, Arlington, TX live on NBC at 8:20 p.m. ET.
When is Monday night football of NFL Week 16 in 2021?
The Miami Dolphins vs New Orleans Saints is set for the 2021 Monday night football at NFL Week 16 on Monday, December 20 at Caesars Superdome, New Orleans live on ESPN starting at 8:15 p.m. ET.
Thursday, December 23
| Matchups | Time (ET) | TV Channel | Arena Location |
| 49ers @ Titans | 8:20 PM | NFLN | Nissan Stadium |
Saturday, December 25
| Matchups | Time (ET) | TV Channel | Arena Location |
| Browns @ Packers | 4:30 PM | FOX | Lambeau Field |
| Colts @ Cardinals | 8:15 PM | NFLN | State Farm Stadium |
Sunday, December 26
| Matchups | Time (ET) | TV Channel | Arena Location |
| Lions @ Falcons | 1:00 PM | FOX | Mercedes-Benz Stadium |
| Ravens @ Bengals | 1:00 PM | CBS | Paul Brown Stadium |
| Rams @ Vikings | 1:00 PM | FOX | U.S. Bank Stadium |
| Bills @ Patriots | 1:00 PM | CBS | Gillette Stadium |
| Jaguars @ Jets | 1:00 PM | CBS | MetLife Stadium |
| Giants @ Eagles | 1:00 PM | FOX | Lincoln Financial Field |
| Buccaneers @ Panthers | 1:00 PM | FOX | Bank of America Stadium |
| Chargers @ Texans | 1:00 PM | CBS | NRG Stadium |
| Bears @ Seahawks | 4:05 PM | FOX | Lumen Field |
| Steelers @ Chiefs | 4:25 PM | CBS | GEHA Field at Arrowhead Stadium |
| Broncos @ Raiders | 4:25 PM | CBS | Allegiant Stadium |
| Football Team @ Cowboys | 8:20 PM | NBC | AT&T Stadium |
Monday, December 27
| Matchups | Time (ET) | TV Channel | Arena Location |
| Dolphins @ Saints | 8:15 PM | ESPN | Caesars Superdome |