New York Giants vs San Francisco 49ers Results
The New York Giants and San Francisco 49ers played each other in the regular season and playoffs 43 times in league history. New York Giants 21 games and San Francisco 49ers won 22 games in their all-time meeting here listed below.
San Francisco 49ers lead alltime series 22-21-0.
| When | Where | Results |
| 09/21/2023 | New York Giants at San Francisco 49ers | 49ers (30-12) |
| 09/27/2020 | San Francisco 49ers at New York Giants | 36-9 (Francisco 49ers) |
| 11/12/2018 | New York Giants at San Francisco 49ers | 27-23 (Giants) |
| 11/12/2017 | New York Giants at San Francisco 49ers | 21-31 (Francisco 49ers) |
| 10/11/2015 | San Francisco 49ers at New York Giants | 27-30 (Giants) |
| 11/16/2014 | San Francisco 49ers at New York Giants | 16-10 (Francisco 49ers) |
| 10/14/2012 | New York Giants at San Francisco 49ers | 26-3 (Giants) |
| 01/22/2012 | New York Giants at San Francisco 49ers | 20-17 (Giants) |
| 11/13/2011 | New York Giants at San Francisco 49ers | 20-27 (Francisco 49ers) |
| 10/19/2008 | San Francisco 49ers at New York Giants | 17-29 (Giants) |
| 10/21/2007 | San Francisco 49ers at New York Giants | 15-33 (Giants) |
| 11/06/2005 | New York Giants at San Francisco 49ers | 24-6 (Giants) |
| 01/05/2003 | New York Giants at San Francisco 49ers | 38-39 (Francisco 49ers) |
| 09/05/2002 | San Francisco 49ers at New York Giants | 16-13 (Francisco 49ers) |
| 11/30/1998 | New York Giants at San Francisco 49ers | 7-31 (Francisco 49ers) |
| 10/01/1995 | New York Giants at San Francisco 49ers | 6-20 (Francisco 49ers) |
| 01/15/1994 | New York Giants at San Francisco 49ers | 3-44 (Francisco 49ers) |
| 09/06/1992 | San Francisco 49ers at New York Giants | 31-14 (Francisco 49ers) |
| 09/02/1991 | San Francisco 49ers at New York Giants | 14-16 (Giants) |
| 01/20/1991 | New York Giants at San Francisco 49ers | 15-13 (Giants) |
| 12/03/1990 | New York Giants at San Francisco 49ers | 3-7 (Francisco 49ers) |
| 11/27/1989 | New York Giants at San Francisco 49ers | 24-34 (Francisco 49ers) |
| 09/11/1988 | San Francisco 49ers at New York Giants | 20-17 (Francisco 49ers) |
| 10/05/1987 | San Francisco 49ers at New York Giants | 41-21 (Francisco 49ers) |
| 01/04/1987 | San Francisco 49ers at New York Giants | 3-49 (Giants) |
| 12/01/1986 | New York Giants at San Francisco 49ers | 21-17 (Giants) |
| 12/29/1985 | San Francisco 49ers at New York Giants | 3-17 (Giants) |
| 12/29/1984 | New York Giants at San Francisco 49ers | 10-21 (Francisco 49ers) |
| 10/08/1984 | San Francisco 49ers at New York Giants | 31-10 (Francisco 49ers) |
| 01/03/1982 | New York Giants at San Francisco 49ers | 24-38 (Francisco 49ers) |
| 11/29/1981 | New York Giants at San Francisco 49ers | 10-17 (Francisco 49ers) |
| 11/23/1980 | New York Giants at San Francisco 49ers | 0-12 (Francisco 49ers) |
| 10/14/1979 | San Francisco 49ers at New York Giants | 16-32 (Giants) |
| 09/24/1978 | San Francisco 49ers at New York Giants | 10-27 (Giants) |
| 10/16/1977 | San Francisco 49ers at New York Giants | 17-20 (Giants) |
| 12/21/1975 | New York Giants at San Francisco 49ers | 26-23 (Giants) |
| 10/15/1972 | New York Giants at San Francisco 49ers | 23-17 (Giants) |
| 10/20/1968 | San Francisco 49ers at New York Giants | 26-10 (Francisco 49ers) |
| 11/17/1963 | San Francisco 49ers at New York Giants | 14-48 (Giants) |
| 09/25/1960 | New York Giants at San Francisco 49ers | 21-19 (Giants) |
| 12/01/1957 | San Francisco 49ers at New York Giants | 27-17 (Francisco 49ers) |
| 09/30/1956 | New York Giants at San Francisco 49ers | 38-21 (Giants) |
| 11/09/1952 | San Francisco 49ers at New York Giants | 14-23 (Giants) |