Kansas City Chiefs vs San Francisco 49ers Results
The Kansas City Chiefs and San Francisco 49ers played each other in the regular season and playoffs 15 times in league history. Kansas City Chiefs 8 games and the San Francisco 49ers won 7 games in their all-time meeting here listed below.
Kansas City Chiefs leading the all-time series 8-7-0.
| Where | When | Results |
| Kansas City Chiefs at San Francisco 49ers | 10/23/2022 | 44-23 (Chiefs) |
| San Francisco 49ers at Kansas City Chiefs | 02/02/2020 | 20-31 (Chiefs) |
| San Francisco 49ers at Kansas City Chiefs | 09/23/2018 | 27-38 (Chiefs) |
| Kansas City Chiefs at San Francisco 49ers | 10/05/2014 | 17-22 (49ers) |
| San Francisco 49ers at Kansas City Chiefs | 09/26/2010 | 10-31 (Chiefs) |
| San Francisco 49ers at Kansas City Chiefs | 10/01/2006 | 0-41 (Chiefs) |
| Kansas City Chiefs at San Francisco 49ers | 11/10/2002 | 13-17 (49ers) |
| Kansas City Chiefs at San Francisco 49ers | 11/12/2000 | 7-21 (49ers) |
| San Francisco 49ers at Kansas City Chiefs | 11/30/1997 | 9-44 (Chiefs) |
| San Francisco 49ers at Kansas City Chiefs | 09/11/1994 | 17-24 (Chiefs) |
| Kansas City Chiefs at San Francisco 49ers | 12/14/1991 | 14-28 (49ers) |
| Kansas City Chiefs at San Francisco 49ers | 11/17/1985 | 3-31 (49ers) |
| San Francisco 49ers at Kansas City Chiefs | 12/26/1982 | 26-13 (49ers) |
| San Francisco 49ers at Kansas City Chiefs | 10/05/1975 | 20-3 (49ers) |
| Kansas City Chiefs at San Francisco 49ers | 12/06/1971 | 26-17 (Chiefs) |