Indianapolis Colts vs San Francisco 49ers Results
The Indianapolis Colts and San Francisco 49ers played each other in the regular season and playoffs 46 times in league history. Indianapolis Colts 27 games and San Francisco 49ers won 19 games in their all-time meeting here listed below.
Indianapolis Colts leading the all-time series 27-19-0.
| When | Where | Results |
| 10/24/2021 | Indianapolis Colts at San Francisco 49ers | 30-18 (Colts) |
| 10/08/2017 | San Francisco 49ers at Indianapolis Colts | 23-26 (Colts) |
| 09/22/2013 | Indianapolis Colts at San Francisco 49ers | 27-7 (Colts) |
| 11/01/2009 | San Francisco 49ers at Indianapolis Colts | 14-18 (Colts) |
| 10/09/2005 | Indianapolis Colts at San Francisco 49ers | 28-3 (Colts) |
| 11/25/2001 | San Francisco 49ers at Indianapolis Colts | 40-21 (Francisco 49ers) |
| 10/18/1998 | Indianapolis Colts at San Francisco 49ers | 31-34 (Francisco 49ers) |
| 10/15/1995 | San Francisco 49ers at Indianapolis Colts | 17-18 (Colts) |
| 09/10/1989 | San Francisco 49ers at Indianapolis Colts | 30-24 (Francisco 49ers) |
| 10/05/1986 | Indianapolis Colts at San Francisco 49ers | 14-35 (Francisco 49ers) |
| 11/12/1972 | Baltimore Colts at San Francisco 49ers | 21-24 (Francisco 49ers) |
| 11/16/1969 | Baltimore Colts at San Francisco 49ers | 17-20 (Francisco 49ers) |
| 10/26/1969 | San Francisco 49ers at Baltimore Colts | 24-21 (Francisco 49ers) |
| 10/13/1968 | Baltimore Colts at San Francisco 49ers | 42-14 (Colts) |
| 09/15/1968 | San Francisco 49ers at Baltimore Colts | 10-27 (Colts) |
| 11/26/1967 | Baltimore Colts at San Francisco 49ers | 26-9 (Colts) |
| 10/01/1967 | San Francisco 49ers at Baltimore Colts | 7-41 (Colts) |
| 12/18/1966 | Baltimore Colts at San Francisco 49ers | 30-14 (Colts) |
| 09/25/1966 | San Francisco 49ers at Baltimore Colts | 14-36 (Colts) |
| 10/31/1965 | Baltimore Colts at San Francisco 49ers | 34-28 (Colts) |
| 10/03/1965 | San Francisco 49ers at Baltimore Colts | 24-27 (Colts) |
| 11/29/1964 | Baltimore Colts at San Francisco 49ers | 14-3 (Colts) |
| 11/01/1964 | San Francisco 49ers at Baltimore Colts | 7-37 (Colts) |
| 10/13/1963 | San Francisco 49ers at Baltimore Colts | 3-20 (Colts) |
| 09/22/1963 | Baltimore Colts at San Francisco 49ers | 20-14 (Colts) |
| 11/04/1962 | Baltimore Colts at San Francisco 49ers | 22-3 (Colts) |
| 10/07/1962 | San Francisco 49ers at Baltimore Colts | 21-13 (Francisco 49ers) |
| 12/16/1961 | Baltimore Colts at San Francisco 49ers | 27-24 (Colts) |
| 12/03/1961 | San Francisco 49ers at Baltimore Colts | 17-20 (Colts) |
| 12/18/1960 | Baltimore Colts at San Francisco 49ers | 10-34 (Francisco 49ers) |
| 11/27/1960 | San Francisco 49ers at Baltimore Colts | 30-22 (Francisco 49ers) |
| 12/05/1959 | Baltimore Colts at San Francisco 49ers | 34-14 (Colts) |
| 11/22/1959 | San Francisco 49ers at Baltimore Colts | 14-45 (Colts) |
| 12/14/1958 | Baltimore Colts at San Francisco 49ers | 12-21 (Francisco 49ers) |
| 11/30/1958 | San Francisco 49ers at Baltimore Colts | 27-35 (Colts) |
| 12/08/1957 | Baltimore Colts at San Francisco 49ers | 13-17 (Francisco 49ers) |
| 11/24/1957 | San Francisco 49ers at Baltimore Colts | 21-27 (Colts) |
| 12/16/1956 | Baltimore Colts at San Francisco 49ers | 17-30 (Francisco 49ers) |
| 12/02/1956 | San Francisco 49ers at Baltimore Colts | 20-17 (Francisco 49ers) |
| 12/11/1955 | Baltimore Colts at San Francisco 49ers | 24-35 (Francisco 49ers) |
| 11/27/1955 | San Francisco 49ers at Baltimore Colts | 14-26 (Colts) |
| 12/11/1954 | Baltimore Colts at San Francisco 49ers | 7-10 (Francisco 49ers) |
| 11/28/1954 | San Francisco 49ers at Baltimore Colts | 13-17 (Colts) |
| 12/13/1953 | Baltimore Colts at San Francisco 49ers | 14-45 (Francisco 49ers) |
| 11/29/1953 | San Francisco 49ers at Baltimore Colts | 38-21 (Francisco 49ers) |
| 10/29/1950 | Baltimore Colts at San Francisco 49ers | 14-17 (Francisco 49ers) |