Detroit Lions vs Buffalo Bills Results
The Buffalo Bills and Detroit Lions played each other in the regular season and playoffs 12 times in league history. Buffalo Bills 7 games and Detroit Lions won 4 games in their all-time meeting here listed below.
Buffalo Bills leading the all-time series 7-4-1.
| Where | When | Results |
| Buffalo Bills at Detroit Lions | 11/24/2022 | 28-25 (Bills) |
| Detroit Lions at Buffalo Bills | 12/16/2018 | 13-14 (Bills) |
| Buffalo Bills at Detroit Lions | 10/05/2014 | 17-14 (Bills) |
| Detroit Lions at Buffalo Bills | 11/14/2010 | 12-14 (Bills) |
| Buffalo Bills at Detroit Lions | 10/15/2006 | 17-20 (Lions) |
| Detroit Lions at Buffalo Bills | 10/27/2002 | 17-24 (Bills) |
| Detroit Lions at Buffalo Bills | 10/05/1997 | 13-22 (Bills) |
| Buffalo Bills at Detroit Lions | 11/24/1994 | 21-35 (Lions) |
| Detroit Lions at Buffalo Bills | 12/22/1991 | 17-14 (Lions) |
| Detroit Lions at Buffalo Bills | 10/28/1979 | 20-17 (Bills) |
| Buffalo Bills at Detroit Lions | 11/25/1976 | 14-27 (Lions) |
| Detroit Lions at Buffalo Bills | 12/10/1972 | 21-21 (Tie) |