San Francisco 49ers vs Carolina Panthers Results
The Carolina Panthers and San Francisco 49ers played each other in the regular season and playoffs 23 times in league history. Carolina Panthers 13 games and the San Francisco 49ers won 10 games in their all-time meeting here listed below.
Carolina Panthers leading the all-time series 13-10-0
| Where | When | Results |
| San Francisco 49ers at Carolina Panthers | 10/09/2022 | 37-15 (49ers) |
| Carolina Panthers at San Francisco 49ers | 10/27/2019 | 13-51 (49ers) |
| Carolina Panthers at San Francisco 49ers | 09/10/2017 | 23-3 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 09/18/2016 | 27-46 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 01/12/2014 | 23-10 (49ers) |
| Carolina Panthers at San Francisco 49ers | 11/10/2013 | 10-9 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 10/24/2010 | 20-23 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 12/02/2007 | 14-31 (Panthers) |
| Carolina Panthers at San Francisco 49ers | 11/14/2004 | 37-27 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 11/18/2001 | 25-22 (49ers) |
| Carolina Panthers at San Francisco 49ers | 10/07/2001 | 14-24 (49ers) |
| San Francisco 49ers at Carolina Panthers | 10/22/2000 | 16-34 (Panthers) |
| Carolina Panthers at San Francisco 49ers | 09/10/2000 | 38-22 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 12/18/1999 | 24-41 (Panthers) |
| Carolina Panthers at San Francisco 49ers | 10/17/1999 | 31-29 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 12/06/1998 | 31-28 (49ers) |
| Carolina Panthers at San Francisco 49ers | 11/08/1998 | 23-25 (49ers) |
| Carolina Panthers at San Francisco 49ers | 11/16/1997 | 19-27 (49ers) |
| San Francisco 49ers at Carolina Panthers | 09/29/1997 | 34-21 (49ers) |
| Carolina Panthers at San Francisco 49ers | 12/08/1996 | 30-24 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 09/22/1996 | 7-23 (Panthers) |
| San Francisco 49ers at Carolina Panthers | 12/10/1995 | 31-10 (49ers) |
| Carolina Panthers at San Francisco 49ers | 11/05/1995 | 13-7 (Panthers) |