The 2021-22 NFL Week 8 game will kick off on Thursday, October 28 with a game where the Arizona Cardinals host the Green Bay Packers at 8:20 pm ET on NFLN, and Week 8 football will be ended with a game where the New York Giants will visit Kansas City Chiefs Monday, November 1 at 8:15 pm ET on ESPN.
Thursday, October 27
| Matchup | Time (ET) | TV | Arena Location |
| Ravens @ Buccaneers | 8:15 PM | Prime Video | Raymond James Stadium, Tampa |
Sunday, October 30
| Matchup | Time (ET) | TV | Arena Location |
| Broncos @ Jaguars | 9:30 AM | ESPN | Wembley Stadium, London |
| Panthers @ Falcons | 1:00 PM | FOX | Mercedes-Benz Stadium, Atlanta |
| Bears @ Cowboys | 1:00 PM | FOX | AT&T Stadium, Arlington |
| Dolphins @ Lions | 1:00 PM | CBS | Ford Field, Detroit |
| Cardinals @ Vikings | 1:00 PM | FOX | U.S. Bank Stadium, Minneapolis |
| Las Vegas @ Saints | 1:00 PM | CBS | Caesars Superdome, New Orleans |
| Patriots @ New York | 1:00 PM | CBS | MetLife Stadium, East Rutherford |
| Steelers @ Eagles | 1:00 PM | CBS | Lincoln Financial Field, Philadelphia |
| Titans @ Texans | 4:05 PM | CBS | NRG Stadium, Houston |
| Commanders @ Colts | 4:25 PM | FOX | Lucas Oil Stadium, Indianapolis |
| 49ers @ Los Angeles | 4:25 PM | FOX | SoFi Stadium, Inglewood |
| New York @ Seahawks | 4:25 PM | FOX | Lumen Field, Seattle |
| Packers @ Bills | 8:20 PM | NBC | Highmark Stadium, Orchard Park |
Monday, October 31
| Matchup | Time (ET) | TV | Arena Location |
| Bengals @ Browns | 8:15 PM | ESPN | FirstEnergy Stadium, Cleveland |