The 2021 NFL Week 4 game will kick off on Thursday, September 30 the Cincinnati Bengals hosting the Jacksonville Jaguars at 8:20 pm ET on NFLN, and in the Sunday Night Football between Tampa Bay Buccaneers will visit New England Patriots at 8:20 pm ET on NBC, and Week 4 will conclude with Philadelphia Eagles visit Dallas Cowboys Monday, October 4 at 8:15 pm ET on ESPN.
Thursday, September 29
| Matchup | Time (ET) | TV | Arena Location |
| Dolphins @ Bengals | 8:15 PM | Prime Video | Paul Brown Stadium, Cincinnati |
Sunday, October 2
| Matchup | Time (ET) | TV | Arena Location |
| Vikings @ Saints | 9:30 AM | NFLN | Tottenham Hotspur Stadium, London |
| Browns @ Falcons | 1:00 PM | CBS | Mercedes-Benz Stadium, Atlanta |
| Commanders @ Cowboys | 1:00 PM | FOX | AT&T Stadium, Arlington |
| Seahawks @ Lions | 1:00 PM | FOX | Ford Field, Detroit |
| Titans @ Colts | 1:00 PM | FOX | Lucas Oil Stadium, Indianapolis |
| Bears @ New York | 1:00 PM | FOX | MetLife Stadium, East Rutherford |
| Jaguars @ Eagles | 1:00 PM | CBS | Lincoln Financial Field, Philadelphia |
| New York @ Steelers | 1:00 PM | CBS | Heinz Field, Pittsburgh |
| Bills @ Ravens | 1:00 PM | CBS | M&T Bank Stadium, Baltimore |
| Los Angeles @ Texans | 1:00 PM | CBS | NRG Stadium, Houston |
| Cardinals @ Panthers | 4:05 PM | FOX | Bank of America Stadium, Charlotte |
| Patriots @ Packers | 4:25 PM | CBS | Lambeau Field, Green Bay |
| Broncos @ Las Vegas | 4:25 PM | CBS | Allegiant Stadium, Las Vegas |
| Chiefs @ Buccaneers | 8:20 PM | NBC | Raymond James Stadium, Tampa |
Monday, October 3
| Matchup | Time (ET) | TV | Arena Location |
| Los Angeles @ 49ers | 8:15 PM | ESPN | Levi’s Stadium, Santa Clara |