Los Angeles Chargers vs San Francisco 49ers Results
The Los Angeles Chargers and San Francisco 49ers played each other in the regular season and playoffs 16 times in league history. Los Angeles Chargers 8 games and the San Francisco 49ers won 8 games in their all-time meeting here listed below.
The all-time series is tied 8-8-0.
| When | Where | Results |
| 11/13/2022 | Los Angeles Chargers at San Francisco 49ers | 22-16 (49ers) |
| 09/30/2018 | San Francisco 49ers at Los Angeles Chargers | 27-29 (Chargers) |
| 12/20/2014 | San Diego Chargers at San Francisco 49ers | 38-35 (Chargers) |
| 12/16/2010 | San Francisco 49ers at San Diego Chargers | 7-34 (Chargers) |
| 10/15/2006 | San Diego Chargers at San Francisco 49ers | 48-19 (Chargers) |
| 11/17/2002 | San Francisco 49ers at San Diego Chargers | 17-20 (Chargers) |
| 12/03/2000 | San Francisco 49ers at San Diego Chargers | 45-17 (49ers) |
| 11/23/1997 | San Diego Chargers at San Francisco 49ers | 10-17 (49ers) |
| 01/29/1995 | San Diego Chargers at San Francisco 49ers | 26-49 (49ers) |
| 12/11/1994 | San Francisco 49ers at San Diego Chargers | 38-15 (49ers) |
| 09/08/1991 | San Diego Chargers at San Francisco 49ers | 14-34 (49ers) |
| 11/27/1988 | San Francisco 49ers at San Diego Chargers | 48-10 (49ers) |
| 12/11/1982 | San Diego Chargers at San Francisco 49ers | 41-37 (Chargers) |
| 09/30/1979 | San Francisco 49ers at San Diego Chargers | 9-31 (Chargers) |
| 12/05/1976 | San Francisco 49ers at San Diego Chargers | 7-13 (Chargers) |
| 09/17/1972 | San Diego Chargers at San Francisco 49ers | 3-34 (49ers) |