Jacksonville Jaguars vs San Francisco 49ers Results
The Jacksonville Jaguars and San Francisco 49ers played each other in the regular season and playoffs 6 times in league history. Jacksonville Jaguars 2 games and San Francisco 49ers won 4 games in their all-time meeting here listed below.
San Francisco 49ers leading the all-time series 4-2-0.
| Where | When | Results |
| San Francisco 49ers at Jacksonville Jaguars | 11/21/2021 | 30-10 (49ers) |
| Jacksonville Jaguars at San Francisco 49ers | 12/24/2017 | 33-44 (49ers) |
| San Francisco 49ers at Jacksonville Jaguars | 10/27/2013 | 42-10 (49ers) |
| Jacksonville Jaguars at San Francisco 49ers | 11/29/2009 | 3-20 (49ers) |
| San Francisco 49ers at Jacksonville Jaguars | 12/18/2005 | 9-10 (Jaguars) |
| San Francisco 49ers at Jacksonville Jaguars | 09/12/1999 | 3-41 (Jaguars) |