The Jacksonville Jaguars and San Francisco 49ers played each other in the regular season and playoffs 6 times in league history. Jacksonville Jaguars 2 games and San Francisco 49ers won 4 games in their all-time meeting here listed below.
San Francisco 49ers leading the all-time series 4-2-0.
|San Francisco 49ers at Jacksonville Jaguars||11/21/2021||30-10 (49ers)|
|Jacksonville Jaguars at San Francisco 49ers||12/24/2017||33-44 (49ers)|
|San Francisco 49ers at Jacksonville Jaguars||10/27/2013||42-10 (49ers)|
|Jacksonville Jaguars at San Francisco 49ers||11/29/2009||3-20 (49ers)|
|San Francisco 49ers at Jacksonville Jaguars||12/18/2005||9-10 (Jaguars)|
|San Francisco 49ers at Jacksonville Jaguars||09/12/1999||3-41 (Jaguars)|