Houston Texans vs San Francisco 49ers Results
The Houston Texans and San Francisco 49ers played each other in the regular season and playoffs 5 times in league history. Houston Texans 1 game and San Francisco 49ers won 4 games in their all-time meeting here listed below.
San Francisco 49ers leading the all-time series 4-1-0.
| When | Where | Results |
| 01/02/2022 | Houston Texans at San Francisco 49ers | 7-23 (Francisco 49ers) |
| 12/10/2017 | San Francisco 49ers at Houston Texans | 26-16 (Francisco 49ers) |
| 10/06/2013 | Houston Texans at San Francisco 49ers | 3-34 (Francisco 49ers) |
| 10/25/2009 | San Francisco 49ers at Houston Texans | 21-24 (Texans) |
| 01/01/2006 | Houston Texans at San Francisco 49ers | 17-20 (Francisco 49ers) |