Detroit Lions vs San Francisco 49ers Results
The Detroit Lions and San Francisco 49ers played each other in the regular season and playoffs 68 times in league history. Detroit Lions 28 games and San Francisco 49ers won 39 games in their all-time meeting here listed below.
San Francisco 49ers leading the all-time series 39-28-1.
| Where | When | Results | |
| San Francisco 49ers at Detroit Lions | 09/12/2021 | 41-33 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 09/16/2018 | 27-30 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 12/27/2015 | 17-32 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 09/16/2012 | 19-27 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 10/16/2011 | 25-19 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/27/2009 | 6-20 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 09/21/2008 | 13-31 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 11/12/2006 | 19-13 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/05/2003 | 17-24 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 11/04/2001 | 13-21 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/14/1998 | 13-35 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/23/1996 | 14-24 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 09/25/1995 | 24-27 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/09/1994 | 27-21 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 12/19/1993 | 55-17 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/28/1992 | 6-24 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/20/1991 | 3-35 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/02/1988 | 13-20 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 10/20/1985 | 21-23 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 09/02/1984 | 30-27 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/31/1983 | 23-24 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 09/06/1981 | 17-24 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 11/02/1980 | 13-17 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 12/17/1978 | 14-33 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 10/23/1977 | 7-28 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 11/02/1975 | 28-17 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/14/1974 | 13-17 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 11/04/1973 | 20-30 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 12/19/1971 | 27-31 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 11/22/1970 | 7-28 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/02/1969 | 26-14 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/27/1968 | 14-7 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/29/1967 | 45-3 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 11/24/1966 | 41-14 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/23/1966 | 24-27 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/05/1965 | 14-17 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 11/14/1965 | 27-21 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 12/13/1964 | 7-24 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 09/13/1964 | 26-17 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/03/1963 | 45-7 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/06/1963 | 3-26 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/11/1962 | 38-24 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 09/23/1962 | 24-45 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/05/1961 | 20-20 (Tie) | T |
| San Francisco 49ers at Detroit Lions | 10/01/1961 | 49-0 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 11/06/1960 | 24-0 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/09/1960 | 14-10 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 11/01/1959 | 7-33 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 10/18/1959 | 34-13 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 11/16/1958 | 21-35 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/02/1958 | 21-24 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/22/1957 | 31-27 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 11/17/1957 | 10-31 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 11/03/1957 | 31-35 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 11/04/1956 | 17-13 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/21/1956 | 17-20 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 10/30/1955 | 21-38 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 10/16/1955 | 27-24 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 11/14/1954 | 7-48 (Lions) | W |
| Detroit Lions at San Francisco 49ers | 10/24/1954 | 31-37 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/25/1953 | 14-10 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/11/1953 | 21-24 (Lions) | W |
| San Francisco 49ers at Detroit Lions | 10/12/1952 | 28-0 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 09/28/1952 | 3-17 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 12/16/1951 | 17-21 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 12/02/1951 | 20-10 (49ers) | L |
| Detroit Lions at San Francisco 49ers | 10/22/1950 | 27-28 (49ers) | L |
| San Francisco 49ers at Detroit Lions | 10/08/1950 | 7-24 (Lions) | W |