Buffalo Bills vs San Francisco 49ers Results
The Buffalo Bills and San Francisco 49ers played each other in the regular season and playoffs 13 times in league history. Buffalo Bills 7 games and San Francisco 49ers won 6 games in their all-time meeting here listed below.
Buffalo Bills leading the all-time series 7-6-0.
| Where | When | Results |
| Buffalo Bills at San Francisco 49ers | 12/07/2020 | 34-24 (Bills) |
| San Francisco 49ers at Buffalo Bills | 10/16/2016 | 16-45 (Bills) |
| Buffalo Bills at San Francisco 49ers | 10/07/2012 | 3-45 (49ers) |
| San Francisco 49ers at Buffalo Bills | 11/30/2008 | 10-3 (49ers) |
| Buffalo Bills at San Francisco 49ers | 12/26/2004 | 41-7 (Bills) |
| Buffalo Bills at San Francisco 49ers | 12/02/2001 | 0-35 (49ers) |
| San Francisco 49ers at Buffalo Bills | 10/04/1998 | 21-26 (Bills) |
| Buffalo Bills at San Francisco 49ers | 12/03/1995 | 17-27 (49ers) |
| Buffalo Bills at San Francisco 49ers | 09/13/1992 | 34-31 (Bills) |
| Buffalo Bills at San Francisco 49ers | 12/17/1989 | 10-21 (49ers) |
| San Francisco 49ers at Buffalo Bills | 12/11/1983 | 23-10 (49ers) |
| Buffalo Bills at San Francisco 49ers | 12/21/1980 | 18-13 (Bills) |
| San Francisco 49ers at Buffalo Bills | 09/24/1972 | 20-27 (Bills) |